Citation: V. Subbarao Boppana, Adam Castaño, Uma Mahesh R Avula, Masatoshi Yamazaki, Jérôme Kalifa
Metformin is an oral antidiabetic drug used for treatment of Type 2 diabetes mellitus (T2DM). It acts by decreasing gluconeogenesis in the liver and absorption of glucose from the gastrointestinal system, in addition to increasing the peripheral utilization of glucose. Metformin is excreted unchanged through the renal route. Severe side effects are noted in patients with renal and/or hepatic dysfunction. These may vary from severe lactic acidosis which can be life threatening, to cardiac arrhythmias.